Vardenafil (in the form of the monohydrochloride trihydrate) 5 mg per tablet. Other ingredients: crospovidone, magnesium stearate, microcrystalline cellulose, colloidal anhydrous silica, polyethylene glycol (macrogol 400), hypromellose (hydroxypropyl methylcellulose), titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172). Levitra - a drug for the treatment of erectile dysfunction, phosphodiesterase inhibitor type 5 (PDE5).
Penile erection is a hemodynamic process based on the relaxation of smooth muscles of cavernous bodies and located in its arterioles. During sexual stimulation of the nerve endings of the cavernous bodies released nitric oxide (of NO), activates the enzyme guanylate cyclase, which leads to higher content in the cavernous bodies of cyclic guanosine monophosphate (cGMP). The result is relaxation of smooth muscles of cavernous bodies, which increases blood flow to the penis.
The drug Levitra blocks PDE-5, which takes place under the influence of the splitting of cGMP, as a result of this action of endogenous NO in the cavernous bodies during sexual stimulation is enhanced, resulting in the ability of Levitra enhances the natural response to sexual stimulation.
The clinical effect of the drug Levitra is realized before reaching Cmax. After oral drug Levitra in doses of 20 mg and 10 mg of onset of action - 10 min, which allows an erection sufficient for penetration and successful completion of intercourse in 34% and 40% of patients with mild to moderate erectile dysfunction, respectively. After 25 minutes, the effect occurs respectively in 53% and 50% of patients, which coincides with the beginning of the appearance of the drug in the blood and a rapid increase of its concentration. Duration - 8-12 hours.
After intake Levitra is rapidly absorbed from the gastrointestinal tract. Cmax is reached, usually after an average of 60 minutes (30 to 120 min). The absolute bioavailability of approximately 15%. When receiving medicament Levitra simultaneously with food containing a large amount of fat, the absorption rate decreases: time to reach Cmax in plasma (Tmax) is increased to 60 minutes, an average Cmax is reduced by 20% without a significant change in AUC. Upon receiving a normal diet, containing no more than 30% fat, vardenafil pharmacokinetic parameters (Cmax, Tmax, AUC) are not changed.
Levitra and its major metabolite are highly bound to plasma proteins (95%), and this property is reversible and not dependent on the total concentration of the drug. After 90 minutes after taking the drug Levitra drug inside in the semen of healthy men found no more than 0.00012% of the administered dose.Levitra is metabolized primarily in the liver with the participation isozymes of cytochrome P450 - CYP3A4, and CYP3A5 and CYP2C9. The average T1 / 2 vardenafil is 4-5 hours, and the main metabolite - about 4 hours. The total clearance of Levitra is 56 l / h, final T1 / 2 - about 4-5 hours. After oral drug Levitra as metabolites excreted mainly via the intestine (91-95% of the dose), less - kidneys (2.6% of dose).
In healthy older men (65 years and older) compared to younger (45 years old and younger) not observed a significant reduction in hepatic clearance of vardenafil. In men older AUC increased on average by 52%. In clinical studies, there was no difference between the efficacy and safety of the elderly and young individuals.
Patients with minor (QC 80-50 mL / min), moderate (creatinine clearance 50-30 ml / min) and severe (creatinine clearance <30 mL / min) renal dysfunction vardenafil pharmacokinetic parameters were comparable to those in healthy subjects. There was no significant correlation between QA and the concentration of vardenafil in the plasma (AUC and Cmax).
In patients on hemodialysis, the pharmacokinetics of vardenafil has not been studied. In patients with mild and moderate hepatic impairment the clearance of the drug Levitra is reduced in proportion to the degree of liver dysfunction. Compared with healthy men, patients with minor hepatic impairment may increase in AUC and Cmax of 1.2 times and at moderate hepatic dysfunction - in 2.6 times. In patients with severely impaired hepatic function The pharmacokinetics of the drug Levitra has not been studied.
The rapid onset of action and duration of, here are the facts, which is different from other drugs of the same action. And are a plus to his characterization. Also, it is compatible with alcohol. The drugs are based on increasing the concentration of cGMP in corpus cavernosum penis via inhibition of PDE5 vardenafil, at a time when released during sexual arousal nitrogen oxide. In this connection, relaxing the smooth muscles of the arteries and blood flow to the penis is increased, an erection. And remember that without this sexual arousal will not effect.Levitra is a well-known drug that helps to solve problems with sexual life. Because the substance contained in the preparation, vardenafil, provided erection for a long time. For many years, men of all ages suffer from this problem, but at this point Levitra is an indispensable tool in this matter and helps to forget the problem.
He is the most excellent, the quality and characteristics by which he is the leader among similar products. It is also compatible with alcohol, but it should not be taken with a particularly large amount of alcohol, it can lead to undesirable consequences. This medication relaxes the muscles of the flat artery providing blood flow to the penis, thus helping the normal course of the processes in the body. The sexual organ is increased, there is a quality erection. But remember that without the presence of sexual arousal effect from it will not.
Creating Levitra, the highest level specialists wanted to achieve great results and a minimum of adverse effects. And they succeeded. Of course, due to the heavy and expensive research price of the drug is high, but it proves once again that the drug acts and, taking it before having sex, you can always be sure that it will happen at a high level. Never trust people who offer you to buy the drug for a small sum. Most likely, this drug would be fake and will produce the desired effect on your body. Try to buy Generic Levitra in the audited areas or on the recommendations of experts.
The active substance which is the main component of the drug - Vardenafil, is a generalized chemical component. Therefore, it is possible to say that, either in the products, fruits, medicinal plants, these substances can not be found. Based on this matter at the highest level has developed a medication Levitra. The creation of Levitra involved a group of specialists in this field. First, they generalize these substances, and then they began to study the substance and the dose at which it can be taken. They have achieved a good combination of quality and price, also reached the optimal doses for maximum effect and minimal side effects.
Specialists in the field of pharmacology substance synthesis technology developed for the purification of mixtures of Levitra and other components, which often cause allergic reaction, or they lead to adverse consequences. Release Levitra is made for the present in the form of tablets of 2.5 - 40 mg. The main active ingredient in this preparation - Vardenafil. Do tablets have a planar shape, they are coated with a yellow and red tint. Each tablet contains the number of milligrams therein. The most common drug for increasing the potency of man is Levitra.
This drug affects the natural reaction, and creates a natural process of sexual arousal and a good erection. We can not say that because of this drug comes full sexual intercourse. It should be emphasized that Levitra is the only assistant of natural needs of the organism. This means that your desire and opportunity in the first place, and the drug will help strengthen these processes and to reach the highest point.
When excited at the penis arteries dilate men, an increase in blood flow occurs, his penis gets up, namely the erection begins. Levitra helps increase significantly, a rush of blood to the penis. Special material, which is a part of the preparation allows to increase with better effect of the arteries and high blood flow is achieved through this. And because substance vardenafil it helps to prolong the effect, a longer period of time due to the expansion of blood vessels and arteries. According from the above that the active drug is a vasodilator, however, the fact is that it is not inducing an erection, it can not operate by itself. Activation requires natural stimulation of the organism.
Because it is necessary to expand the arteries nitric oxide, which appears in the body only if the natural sexual arousal, the drug may not by itself. He can not, without a natural excitation, increasing the arteries and blood flow to the penis, so as usual excitement, natural, sexy can cause the release of nitric oxide on the order of the spinal cord or brain. Thanks to nitrogen oxide is an expansion of the arteries and blood flow to the penis. This drug, which contains the active ingredient vardenafil, helps increase the natural action of excitation processes in the body, and extending the strength and duration of the process.
We also want to once again draw your attention to the fact that the drug does not affect reproductive function. In the study of the drug revealed that after receiving the semen found in the minimum, a small dose of vardenafil. This means that you can not be afraid of the influence of the drug on reproductive function. And in some moments it could be called assistant. Getting used to the drug, based on the results of a study in volunteers, never arises. This drug is available for sale in all areas of pharmacy and online stores. It is worth it is not cheap, it is due to the fact that huge amounts of money spent on the development of this unique product and patent registration. But now you can be sure that the drug is the brand and guarantees excellent quality and safety.
Be wary of the drug Levitra in patients with anatomical deformation of the penis (curved, cavernous fibrosis or Peyronie's disease), as well as in patients with diseases predisposing to the development of priapism (sickle-cell anemia, multiple myeloma or leukemia).
Safety Levitra has not been studied, and the use of the drug is not recommended in patients with severe hepatic impairment; in renal disease in the terminal stage, requiring dialysis; arterial hypotension (systolic blood pressure at rest of less than 90 mm Hg); recent stroke or myocardial infarction (within the last 6 months); unstable angina; with hereditary degenerative retinal disorders (for example, retinitis pigmentosa).
Because Levitra has not been used in patients with a tendency to bleeding, and in patients with acute exacerbation of peptic ulcer disease, use of the drug in these cases is possible only after a careful assessment of risk-benefit of treatment.
In studies in humans, while the use of the drug Levitra as monotherapy were not observed changes krovotecheniya.v time Due to the fact that the sexual activity is associated with a certain degree of cardiac risk before prescribing the drug Levitra for erectile dysfunction is necessary to assess the state of the cardiovascular system patient.
Use in pediatric drug Levitra:
Vardenafil is not intended for use in children.
Effects on ability to drive vehicles and management mechanisms.
Before the appointment Levitra medication to patients who are driving a vehicle and work with the mechanisms necessary to clarify their individual response to Levitra.
Levitra drug is metabolized primarily in the liver, with the participation isozymes of cytochrome P450, especially CYP3A4, and also involving a certain isozymes CYP3A5 and CYP2C9. As potent inhibitors of these enzymes (cimetidine, ketoconazole, itraconazole, indinavir, ritonavir) may decrease the clearance of the drug Levitra, while the use of these drugs should not exceed the maximum dose of Levitra 5 mg / day.
In an application with the CYP3A4 inhibitor erythromycin is recommended not to exceed the maximum dose of Levitra is 10 mg / day. With simultaneous use of Levitra with alpha-blockers may develop symptomatic hypotension. Therefore Levitra 5 mg, 10 mg and 20 mg should be administered no earlier than 6 h after administration of alpha-adrenergic blocker.
With the simultaneous use of the drug Levitra with glibenclamide, nifedipine, warfarin and digoxin no significant changes in the pharmacokinetics. With simultaneous use of warfarin was not observed changes in prothrombin time and clotting factors.
In an application with acetylsalicylic acid, antacids, ACE inhibitors, beta-blockers, diuretics, hypoglycemic agents (sulfonylureas and metformin), as well as histamine H2-receptor - ranitidine and cimetidine pharmacokinetics of vardenafil has not changed. In studies in humans, while the use of vardenafil with acetylsalicylic acid was not observed changes in bleeding time.
Simultaneous administration of heparin and vardenafil rats bleeding time remained unchanged. The impact of this combination on bleeding time in humans has not been studied. Since PDE inhibitors affect the system of nitric oxide / cGMP, PDE5 inhibitors may potentiate the hypotensive effect of nitrates.
In studies on human platelets in vitro showed that monotherapy vardenafil not inhibit platelet aggregation induced by various agonists platelets. When using vardenafil at doses exceeding therapeutic, there was a slight increase in a dose-dependent effect of sodium nitroprusside antiagregatsionnogo - the drug, which is a donor of nitric oxide. Since the safety and efficacy of combinations of Levitra with other agents for the treatment of erectile dysfunction has not been studied, the use of such combinations is not recommended.
At the first receptions can experience minimal side effects such as headache and dizziness. This is normal after administration, because the drug, in general, is a vasodilator and of possible occurrence of a minimum of side effects.But in the future at a constant data reception Levitra negative effects smoothed or disappear entirely. Please note that many men do not routinely experience certain feelings and there are claims to the drug. For example, by increasing the erection Levitra extends sexual intercourse and intercourse completion increases compared with the normal state. Many speak about this on the negative side. But we can assure you that this fact plays in your favor, as the weaker sex, in this case, is experiencing a great pleasure and a test of the drug, many volunteers were told that their other halves were delighted. Therefore, a statement on patients that this medication does not end the sexual act, we can confidently say that this is not a side effect, and is specially created for this purpose.
Since Levitra is created to improve erectile function in men, and the extension of intercourse is a plus to this, this effect is quite normal when taking this drug. Another complained that when taking this drug starts headache and muscle pain with such force that discourages all desire to have sex. We would like to assure you that in numerous studies and all of the volunteers had never seen such side effects and perhaps these results are just coincidence or patients who have experienced this feeling violated soluble dose or taking the medication disrupting the application or advice specialists instructions.
Levitra is a better development in the pharmaceutical field. With the latest equipment and high technology in modern times, scientists have turned to synthesize a substance Vardenafil. It is an active ingredient of Levitra. Because of this when using the drug can achieve positive results in the area of sexual intercourse. It helps not only to deal with erectile dysfunction, but also to extend the duration of sexual intercourse. So he is in the blood in a long time that allows you to be sure, that at any moment you will be able to show their best side in the sexual arena.
Today, the pharmaceutical market there is a huge amount of drugs that significantly improve erections in the male half of the population. But the drug exceeds all expectations. In contrast, it is unique, he has a lot of positive qualities, and minimal side effects. For example, everybody knows Viagra starts to act more slowly, and the effect did not last long. Which leads to the fact that you constantly have to expect while taking this drug.
Note that the drug is in the blood for a long time and is therefore not desirable to take more than one tablet per day, and the daily dose is 20 mg. There are also present in the tablet formulation with other dosages, 5 mg, 10 mg and 40 mg. And in the future you will be able to understand what dose is optimal for you. For example, many men, after the first dose of Levitra, reduce the number of the receiving machine. But in all there are cases when you need to be very confident of a positive result, and in these moments some experts, doctors and patients who are already taking the drug, it is advised to increase the dose of the drug.
But remember that there is a risk of overdose of Levitra. When receiving 500 mg per once serious side effects were observed. In patients was increased pressure appeared angina, increased sweating, pain in the eyes and back and more, up to the instant cardiac arrest, so the recommended maximum dose per day of the drug is 40 mg. Try to stick to this recommendation, in order to avoid future bad consequences. Nor can one day to take multiple doses of 40-100 mg, it will give a similar effect and can lead to adverse side effects.